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Head to head, from our own archive
San Francisco 49ers and Buffalo Bills have met 6 times on this desk, first in 2004 and most recently in 2024. San Francisco 49ers have won 2, Buffalo Bills 4. Aggregate score 112–161.
02.12.24
NFL
Buffalo Bills
San Francisco 49ers
35
10
08.12.20
NFL
San Francisco 49ers
Buffalo Bills
24
34
16.10.16
NFL
Buffalo Bills
San Francisco 49ers
45
16
07.10.12
NFL
San Francisco 49ers
Buffalo Bills
45
3
30.11.08
NFL
Buffalo Bills
San Francisco 49ers
3
10
26.12.04
NFL
San Francisco 49ers
Buffalo Bills
7
41
Buffalo Bills
San Francisco 49ers
35
10
08.12.20
NFL
San Francisco 49ers
Buffalo Bills
24
34
16.10.16
NFL
Buffalo Bills
San Francisco 49ers
45
16
07.10.12
NFL
San Francisco 49ers
Buffalo Bills
45
3
30.11.08
NFL
Buffalo Bills
San Francisco 49ers
3
10
26.12.04
NFL
San Francisco 49ers
Buffalo Bills
7
41
San Francisco 49ers, last matches
25.10.26
NFL
Atlanta Falcons
San Francisco 49ers
29
20
20.10.26
NFL
San Francisco 49ers
Washington Commanders
23
17
11.10.26
NFL
Seattle Seahawks
San Francisco 49ers
29
32
04.10.26
NFL
San Francisco 49ers
Denver Broncos
24
14
27.09.26
NFL
San Francisco 49ers
Arizona Cardinals
36
30
20.09.26
NFL
San Francisco 49ers
Miami Dolphins
35
13
Atlanta Falcons
San Francisco 49ers
29
20
20.10.26
NFL
San Francisco 49ers
Washington Commanders
23
17
11.10.26
NFL
Seattle Seahawks
San Francisco 49ers
29
32
04.10.26
NFL
San Francisco 49ers
Denver Broncos
24
14
27.09.26
NFL
San Francisco 49ers
Arizona Cardinals
36
30
20.09.26
NFL
San Francisco 49ers
Miami Dolphins
35
13
Buffalo Bills, last matches
01.11.26
NFL
Buffalo Bills
Baltimore Ravens
36
10
18.10.26
NFL
Las Vegas Raiders
Buffalo Bills
30
33
13.10.26
NFL
Los Angeles Rams
Buffalo Bills
34
37
04.10.26
NFL
Buffalo Bills
New England Patriots
26
29
27.09.26
NFL
Buffalo Bills
Los Angeles Chargers
24
16
18.09.26
NFL
Buffalo Bills
Detroit Lions
41
31
Buffalo Bills
Baltimore Ravens
36
10
18.10.26
NFL
Las Vegas Raiders
Buffalo Bills
30
33
13.10.26
NFL
Los Angeles Rams
Buffalo Bills
34
37
04.10.26
NFL
Buffalo Bills
New England Patriots
26
29
27.09.26
NFL
Buffalo Bills
Los Angeles Chargers
24
16
18.09.26
NFL
Buffalo Bills
Detroit Lions
41
31
Where they stand
| # | Club | P | GD | Pts |
|---|---|---|---|---|
| 1 | Buffalo Bills |
— | 52 | — |
| 2 | Denver Broncos |
— | 7 | — |
| 3 |  Pittsburgh Steelers |
— | 36 | — |
| 4 |  Jacksonville Jaguars |
— | 85 | — |
| 5 |  Kansas City Chiefs |
— | 36 | — |
| 6 |  Cincinnati Bengals |
— | 48 | — |
| 7 | New England Patriots |
— | 22 | — |
| 8 |  Cleveland Browns |
— | -34 | — |
| 9 | Las Vegas Raiders |
— | -9 | — |
| 10 | Baltimore Ravens |
— | -24 | — |
| 11 |  Houston Texans |
— | -5 | — |
| 12 |  New York Jets |
— | -18 | — |
| 13 |  Indianapolis Colts |
— | -61 | — |
| 14 | Miami Dolphins |
— | -64 | — |
| 15 |  Tennessee Titans |
— | -55 | — |
| 16 | Los Angeles Chargers |
— | -76 | — |
| 1 | San Francisco 49ers |
— | 58 | — |
| 2 |  Minnesota Vikings |
— | 47 | — |
| 3 |  Chicago Bears |
— | 54 | — |
| 4 | Detroit Lions |
— | 23 | — |
| 5 |  Green Bay Packers |
— | 7 | — |
| 6 |  New York Giants |
— | 2 | — |
| 7 | Seattle Seahawks |
— | 26 | — |
| 8 | Los Angeles Rams |
— | 26 | — |
| 9 |  Carolina Panthers |
— | -15 | — |
| 10 |  Tampa Bay Buccaneers |
— | 27 | — |
| 11 | Atlanta Falcons |
— | -18 | — |
| 12 | Arizona Cardinals |
— | -63 | — |
| 13 |  Dallas Cowboys |
— | 6 | — |
| 14 | Washington Commanders |
— | -23 | — |
| 15 |  New Orleans Saints |
— | -32 | — |
| 16 |  Philadelphia Eagles |
— | -65 | — |